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Clinical and immunohistochemical study of eight cases with thymic carcinoma
Conclusions: In this small series, it is suggested that a complete resection suggests a favorable
result. Immunohistochemical results reveal that the expression of these proteins might indicate the
aggressiveness of thymic carcinoma.
Background
Thymic carcinoma is a rare type of malignant tumor [1,2].
It is more invasive and with a poorer prognosis than Thymoma.Read More →

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Conclusion: VATS is an effective and reliable approach for managing mediastinal diseases. Cases of small lesions surrounded by thymic tissue, cystic lesions excluding lymphatic duct ori- gin, and neurogenic tumors without evidence of intraspinal invasion are good indications for VATS. Read More →

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Human thymus development and thymoma behavior remain elusive, in spite of many acquisitions in the field in last decades. In the present paper, we analyzed the immunohistochemical expression of D2-40 in the normal human thymus and thymoma. In both fetal and postnatal normal thymus, we found a strong expression of D2-40 in the subcapsular and cortico-medullary epithelial cells, and lack of expression in the thymus of involution. These findings support a role for podoplanin in the proliferation of some subtypes of epithelial cells of the normal thymus stroma. In thymoma, the expression of D2-40 was detected in neoplastic cells in 18 from 26 cases (69.23%). No correlation was found between D2-40 expression and histological types of thymoma, but strong correlation was noticed with tumor stage. Based on these results, it is suggested that D2-40 expression is a good predictor of invasion and can be considered as a potential target for therapy in selected cases.
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Conclusions.—Carcinoid tumor of the mediastinum is frequently misclassified as thymoma in this program. Al- though some cytologic patterns resemble thymoma, the lack of correlation of these patterns with performance sug- gests that at least part of the reason for misclassification may be failure to consider the correct diagnosis.Read More →