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An ectopic hamartomatous thymoma compressing left jugular vein
Ectopic hamartomatous thymoma (EHT) is an extremely rare benign neoplasm. It is usually found at the root of the neck (frequently on the left) and does not usually impact adjacent tissues in clinically significant ways. While EHT manifests distinct pathological features, the lesion is either asymptomatic or may show nonspecific clinical features. We report one case of EHT which was assumed to be of low malignant potential since it severely compressed the inlet of left internal jugular vein as seen by computed tomography scan. To the best of our knowledge, this clinical finding of EHT is very rare. After the diagnosis and treatment of this patient, we believe that EHT or suspected EHT should be treated less invasively.Read More →

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Acute Presentation of Thymoma With Infarction or Hemorrhage
The presentation of thymomas is variable; most are asymptomatic and others present with local compression symptoms or a parathymic syndrome. Rarely thymomas present as an acute emergency with severe chest painRead More →

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A Multidisciplinary Approach to Therapy for Unresectable Malignant Thymoma
Background: The therapeutic outcome for unresectable, locally advanced, malignant thymoma has been poor.
Objective: To improve tumor resectability and patient survival rates by studying a multimodal approach to therapy for unresectable malignant thymoma.Read More →

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Age, Type of Surgery Linked to Thymoma Relapse Risk in MG Patients
Among myasthenia gravis (MG) patients whose thymomas — tumors of
the thymus — are surgically removed, those who are younger, have a
more advanced thymoma, and whose surgery is other than
a sternotomy or video-assisted thoracic surgery (VATS) appear to be
at a higher risk of cancer relapse, a study from Italy reported.Read More →

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Adjuvant treatment in patients at high risk of recurrence of thymoma: efficacy and safety of a three-dimensional conformal radiation therapy regimen. Conclusion: Adjuvant radiotherapy achieved good local control and showed an acceptable
toxicity profile in patients with high-risk thymomaRead More →

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Autoimmunizing Mechanisms in Thymoma and Thymus
Autoimmunizing mechanisms are very hard to study in humans, so we have focused on vital clues in thymomas and hyperplastic thymuses in myasthenia gravis (MG).Read More →

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Cytogenetic Profile of a Thymoma
A Case Report and Review of the Literature
Cytogenetic analysis of mixed lymphocyte and epithelial
thymoma in a nonmyasthenic female patient revealed deletion of part of the short arm of chromosome 6. To our
knowledge, this cytogenetic abnormality in a benign thymoma has not been previously described in the literature,
which is reviewed.
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Thymomas and thymic carcinoma are rare neoplasms. Surgical resection is the cornerstone of effective therapy. Stage I disease is effectively treated by complete surgical resection. The role of radiation therapy in completely resected stage II disease remains controversial. Adjuvant radiation therapy is useful for local control and may improve survival in patients with incompletely resected tumours. Cisplatin-based chemotherapy regimens play an important role in the treatment of advanced stage III/IV or recurrent disease thymomas, but have proven less effective for thymic carcinoma. Phase II trials of multimodality therapy incorporating neoadjuvant chemotherapy, surgery and postoperative radiation therapy show promise for unresectable disease. This review discusses recent clinical data and the potential role for agents targeting the epidermal growth factor receptor, angiogenesis and apoptotic pathways.Read More →